autism spectrum disorder
Conditions
Interventions
Placebo group:fructo-oligosaccharide
Bifidobacterium breve group:One bag of probiotics per day ( CFU >= 10 ^ 9 )
Bifidobacterium bifidum group:One bag of probiotics per day ( CFU >= 10 ^ 9 )
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
2 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the ASD group: diagnosed as ASD by a child health care physician with rich experience in the clinical diagnosis and treatment of ASD, and the diagnosis conformed to the definition in the Diagnostic and Statistical Manual of Mental Disorders-V (DSM-5). diagnostic criteria; 2. Inclusion criteria for the normal control group: no history of any neuropathic or psychiatric disease; 3. Age 2-10 years old 4. The family members agreed to participate in this interview and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Gastrointestinal surgery; 2. Patients with severe disability; 3. Suffering from serious infectious diseases or infectious diseases; 4. Those who cannot provide correct information; 5. No relatives accompany the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Social responsiveness scale;Autism behavior checklist;PEP-3;Gastrointestinal Symptoms-Rome IV;Fecal flora 16S rRNA amplicon sequencing;metabonomics; | — |
Countries
China
Contacts
Public ContactWang Gang
Jiangnan University
Outcome results
None listed