Lung Caner
Conditions
Interventions
Nonintubated group:Nonintubated anesthesia (paravertebral block+serratus plane block+sedaton)
Control group:Conventional general anesthesia with double-lumen intubation
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients who plan to undergo video-assisted thoracoscopic lobectomy; lung cancer stage T1aN0M0 or T1bN0M0; age 18-64 years old; ASA I-II; BMI 18.5-25kg/m2; the patients voluntarily participated and signed the informed consent.
Exclusion criteria
Exclusion criteria: Expected difficult airway; cardiac dysfunction (frequent ventricular premature beats, atrial fibrillation, EF<50%, coronary heart disease); respiratory dysfunction (FEV1%<50%, no oxygen PaO2<75mmHg or PaCO2<45mmHg); the same History of lateral thoracic surgery; pulmonary infection or tuberculosis; coagulation disorders; neurocognitive dysfunction; pregnancy status; patients receiving long-term opioid therapy, drug abuse, or drug use; inability to receive thoracic paravertebral block and serratus anterior plane block stagnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neutrophil/lymphocyte; | — |
Secondary
| Measure | Time frame |
|---|---|
| peripheral tumor biomarkers (MMP-9, VEGF, bFGF, PD-L1, SII, dNLR/LDH, H3Cit);Intraoperative minimum oxygen saturation;Ratio of transferring to open surgery;Bleeding amount;Recovery time (mobilization, drainage and discharge);Recovery time (mobilization, drainage and discharge);postoperative complication (postoperative pneumothorax, pneumonia, ARDS, atrial fibrillation, hoarseness, sore throat and dysphonia); | — |
Countries
China
Contacts
Public ContactWang Jiafeng
Shanghai Changhai Hospital
Outcome results
None listed