The role of T cell-derived exosomes transferring mitochondrial DNA to reduce the damage of ARDS endothelial cells

Study on the correlation between the concentration of exosomes in alveolar lavage fluid and plasma and the severity and prognosis of lung injury in patients with ARDS

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100052361

Enrollment

Unknown

Registered

2021-10-24

Start date

2021-10-15

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome

Interventions

test group:No

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years old; 2. Meet the Berlin diagnostic criteria for ARDS; 3. An artificial airway has been established (tracheal intubation, tracheotomy); 4. Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Pregnant patients; 2. Cancer patients (including solid tumors and hematological tumors, etc.); 3. Patients with chronic underlying diseases such as acute and chronic hepatitis, liver cirrhosis, COPD, and chronic renal insufficiency; 4. Patients with immunodeficiency diseases; patients who have used glucocorticoids (equivalent dose > prednisone 10 mg/d) or immunosuppressive agents in the 6 months before admission; 5. Patients who have been hospitalized in other hospitals for a long time (>=7 days); 6. Expected survival time < 24h; 7. Patients who participated in other studies within 30 days.

Design outcomes

Primary

Measure	Time frame
Concentration of extracellular vesicles;	—

Countries

China

Contacts

Public ContactHuang Yingzi

Southeast University

yz_huang@126.com+86 13951693278

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026