Alzheimer's disease
Conditions
Interventions
Case series:Nil
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for SCD: (1) Self-perceived continuous decline in cognitive function, independent of acute events, compared with the previous normal state; (2) After adjusting for age, sex and years of education, the standard cognitive test was normal, which was different from MCI and predementias. (1) and (2) must be present together. 2. MCI inclusion criteria: in line with the 2011 NIA-AA core clinical diagnostic criteria for MCI: (1) Clinical manifestations consistent with MCI: 1) Cognitive impairment was reported by patients or informed persons, or found by experienced clinicians; 2) objective evidence of impairment of one or more cognitive domains (from cognitive tests); 3) complex instrumental daily abilities can be slightly impaired, but maintain independent daily living abilities; 4) The diagnosis of dementia has not been reached yet. (2) The pathophysiological process of AD consistent with the pathogenesis: 1) Evidence of continuous decline of cognitive function was found in longitudinal follow-up; 2) There are diseases related to AD genetic factors.
Exclusion criteria
Exclusion criteria: 1. Less than 60 years old; 2. Dementia caused by various causes; 3. Severe physical illness and/or severe mental illness; 4. Cognitive decline caused by vascular, traumatic, iatrogenic, mental illness, medical disease, infection, poisoning, drug side effects or substance abuse, and other neurodegenerative diseases; 5. Impairment of vision and hearing and inability to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RR;AR; | — |
Countries
China
Contacts
Public ContactBi Jianzhong
The Second Hospital of Shandong University
Outcome results
None listed