Urosepsis
Conditions
Interventions
experimental group:intravenous injection vitaminC (2g/d)
control group:intravenous injection normal saline (2g/d)
Sponsors
Guizhou Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The age at the time of enrollment is 18-60 years old; 2. Patients with upper urinary tract calculi by abdominal CT examination and need PNCL treatment according to the treatment guidelines; 3. Blood leukocytes in (4-12) x 10^9/L; 4. Those who have not undergone surgery, radiotherapy or endocrine therapy; 5. ECOG score 0-2 and ASA I-III grade.; 6. The patient or the patient's authorized immediate family has signed the informed consent form for the clinical trial.
Exclusion criteria
Exclusion criteria: 1. There are contraindications to intravenous infusion of high-dose vitamin C, such as severe nausea and vomiting, severe arrhythmia (ventricular tachycardia, ventricular fibrillation) and other diseases that are not suitable for intravenous infusion of high-dose vitamin C: G6PD deficiency, paroxysmal sleep Hemoglobinuria; 2. Those diagnosed with SIRS; 3. Patients with blood system diseases such as anemia, hemophilia, leukemia; 4. Continued use of immunosuppressants or organ transplants and cancer patients within the past 6 months; 5. Patients with renal insufficiency and GFR < 30 ml/min, or patients with liver transaminase greater than 10 times the normal threshold; 6. Those who have participated in other clinical trials within 30 days; 7. Those with poor compliance and unable to follow up as planned.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body temperature;Heart rate;respiration rate;blood pressure;blood platelet count;bilirubin;dopamine;adrenaline;noradrenaline;creatinine;urine volume;clasgow coma score; | — |
Secondary
| Measure | Time frame |
|---|---|
| urine erythrocyte;Urine leukocyte;Urine bacteria;Urine nitrite;numeration of leukocyte;Neutrophil ratio;blood coagulation factor;procalcitonin;C-reactive protein;Abdominal X-ray;abdominal ultrasound scan;Intravenous urography; | — |
Countries
China
Contacts
Public ContactJiang Kehua
Guizhou Provincial People's Hospital
Outcome results
None listed