cardiac surgery under cardiopulmonary bypass
Conditions
Interventions
Experimental group:Ulinastatin for injection on the basis of conventional treatment
Control group:Conventional treatment
Sponsors
Xijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients or their immediate family members signed a written informed consent; 2. Aged 18 to 65 years, no gender limit; 3. Cardiac surgery under cardiopulmonary bypass; 4. Elective surgery.
Exclusion criteria
Exclusion criteria: 1. The clinician believes that it is not suitable for clinical research; 2. Emergency surgery; 3. Patients participating in other clinical studies; 4. Pregnant patients; 5. Patients with infectious diseases; 6. Patients with severe anemia (hemoglobin content <10g/dL).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 at 8 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 ratio and the frequency and ratio of the ratio >= 300 every 4 hours within 72 hours after surgery;Postoperative mechanical ventilation time;Incidence of secondary mechanical ventilation;Incidence of postoperative use of ECMO assistance for respiratory failure;Proportion of postoperative pulmonary infection;Cardiac function-related parameters;Associated inflammatory factors;Renal function-related indexes;Perioperative costs;Safety evaluation indicators; | — |
Countries
China
Contacts
Public ContactJin Zhenxiao
Xijing Hospital
Outcome results
None listed