Diabetic nephropathy
Conditions
Interventions
Experimental group:Basic treatment of western medicine and Baoshenfang granule
Control group:Western medicine basic treatment and comfort granule
Sponsors
Beijing Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnosis of T2DM; 2. Patients who meet the diagnostic criteria of western medicine for diabetic nephropathy stage IV and are combined with diabetic retinopathy, and urine protein =30g/L, glycosylated hemoglobin <8%, serum creatinine <3mg/dl; 3. Patients with deficiency of both qi and yin and blood stasis blocking collaterals; 4. Aged between 18 and 80 years.
Exclusion criteria
Exclusion criteria: 1. Pregnant or planning to become pregnant and lactating patients; 2. Patients with serious primary diseases such as heart, brain, lung, liver and hematopoietic system, allergic constitution; 3. Unable to cooperate, such as mentally ill; 4. There are active infection foci: such as tuberculosis; 5. Patients with renal disease secondary to various tumors and patients with wasting diseases such as tuberculosis; 6. Those who are participating in clinical trials of other drugs or who have participated in other clinical trials within 12 weeks; 7. Glucocorticoids, immunosuppressants, and Tripterygium wilfordii preparations have been used within 12 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine;Urinary albumin to creatinine ratio;24 hour urine protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Soluble advanced glycation end product receptor;Advanced glycation end products in urine;Advanced glycation end products in serum;Connective tissue growth factor;Collagen type IV;Podocyte marker protein;Counting of podocytes with positive expression of FSP-1 antibody;Serum total RNA;miR-21; | — |
Countries
China
Contacts
Public ContactWang Yuefen
Beijing Hospital of Traditional Chinese Medicine
Outcome results
None listed