esophagogastric varices
Conditions
Interventions
group A:Remazolam combined with esmketamine
group B:Propofol combined with esketamine
group C:Sevoflurane combined with esketamine
Sponsors
Liaocheng People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) classification II-III; 2. The diagnostic criteria are in line with the ''Trial Plan for Standardized Endoscopic Diagnosis and Treatment of Digestive Tract Varicose Vein and Hemorrhage (2009)''; 3. The morphology of esophageal varices is grades GII to GIII; 4. Child-Pugh classification of liver function B-C; 5. Platelets > 50 x 10^9/L; 6. The diameter of varicose veins is 0.3-2cm.
Exclusion criteria
Exclusion criteria: 1. Upper gastrointestinal endoscopy is contraindicated; 2. Uncorrected hemorrhagic shock; 3. Portal cavernous degeneration; 4. Budd-Chiari syndrome; 5. Liver tumor; hepatic encephalopathy >= grade 2; 6. Severe cardiopulmonary and renal insufficiency; 7. Suffering from apnea syndrome; 8. Mental illness or receiving psychotropic medication; 9. Alcohol, opioid or sedative-hypnotic addiction; 10. Obesity (body mass index (BMI) > 30kg/m^2); 11. Allergic to the drugs used in the study; 12. For non-initial EVL, the operation time exceeds 40 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of remedies and total amount of drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| General information of patients;Perioperative hemodynamics;Intraoperative anesthetic dosage;Pain score;Operation time;Patient and physician satisfaction;Anesthesia time;Recovery time;Extubation time; | — |
Countries
China
Contacts
Public ContactZhao Tonghang
Liaocheng People's Hospital
Outcome results
None listed