Severe trauma
Conditions
Interventions
Group 1:Protamine is given intravenously
Sponsors
The Second Affiliated Hospital of Xiamen Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 72 Years
Inclusion criteria
Inclusion criteria: The 6 injury sites (head and neck, chest, abdomen, spine, limbs and body surface) were divided into 1-5 points. Then, the score of the three most damaged organs was squared, which was the sum of the squares, which was the ISS score, and the score ranged from 0 to 75 points. Patients with severe trauma were classified as having injury severity Scale (ISS) score >= 16. Severe trauma cases after September 2017 were collected, and the presence of endogenous heparin-like substances was detected by hmTEG on the condition that heparin drugs were not used as prescribed by doctors. The judgment criteria were as follows: Heparinase R-ordinary cup R-value > 5min. The patients confirmed the presence of endogenous heparin-like substances were divided into two groups, group A (protamine intervention group) and group B (no protamine intervention group), with 24 patients each.
Exclusion criteria
Exclusion criteria: Patients with coagulation disorders caused by chronic diseases such as severe liver and kidney diseases and hematologic diseases were excluded from the two groups, and there was no significant difference in age, gender, body weight and ISS score (P > 0.05), indicating comparability. Those without fish allergy detected by allergen were selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thromboelastogram results;AT III;Anti Xa activity;PF4; | — |
Countries
China
Contacts
Public ContactTian Yan
The Second Affiliated Hospital of Xiamen Medical College
Outcome results
None listed