patients requiring PN due to gastrointestinal failure, congenital malformation surgery of the digestive tract, other congenital malformation surgeries, gastrointestinal bleeding, and were expected to
Conditions
Interventions
low-dose MTEI- (I) group:MTEI-(I) at 1 mL/kg/d
high-dose MTEI- (I) group:MTEI-(I) at 2 mL/kg/d
Sponsors
Chengdu Women's and Children's Central Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. patients requiring PN due to gastrointestinal failure, congenital malformation surgery of the digestive tract, other congenital malformation surgeries, gastrointestinal bleeding, and were expected to receive PN for >5 days; 2. patients aged <18 years; 3. patients with no serious cardiac, hepatic (hepatic function index exceeding twice the normal upper limit), renal [below chronic kidney disease (CKD) IV stage], or pulmonary dysfunction; 4. patients where the central venous pathway (subclavian, internal jugular, femoral vein, or peripherally inserted central catheter) was established.
Exclusion criteria
Exclusion criteria: 1. patients with allergies to PN components; 2. patients with diabetes; 3. patients with allergies or adverse reactions to known TEs; 4. patients with obvious trace element deficiencies [iron (Fe), zinc (Zn),copper (Cu), etc.]; 5. patients with congenital metabolic abnormalities; 6. patients with Fe deficient anemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics indicators;Concentration of trace elements in the blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination;liver function;renal function;coagulation function;length of stay; | — |
Countries
China
Contacts
Public ContactZhang Guoying
Chengdu Women's and Children's Central Hospital
Outcome results
None listed