myocardial ischemia in patients with coronary heart disease
Conditions
Interventions
Experimental group:pulse electromagnetic field therapy + conventional therapy of myocardial ischemia
Control group:pulse electromagnetic field placebo therapy + conventional therapy of myocardial ischemia
Sponsors
Zhongshan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18 to 75 years (inclusive), any gender. 2.During the screening period or within the past year, individuals who have undergone coronary angiography (CAG) or coronary computed tomography angiography (CTCA), with no current indication for coronary revascularization or patients unwilling or unable to undergo coronary revascularization. 3.Within the past year before screening, coronary angiography (CAG) or coronary computed tomography angiography (CTCA) showing stenosis of any major coronary vessels (left main, left anterior descending, circumflex, right coronary, diagonal, obtuse marginal, posterior descending, left ventricular posterior branch, etc.) with a luminal diameter greater than 2.5mm, and the degree of stenosis is 80% or less, with corresponding symptoms of myocardial ischemia. 4.Positron emission tomography (PET) showing local myocardial blood flow at rest =2.0ml/min/g (according to the 17-segment model/AHA model, involving at least 2 segments). 5.Echocardiography within the past 6 months showing left ventricular ejection fraction =40%. 6.Ability to tolerate a cardiopulmonary exercise test. 7.Informed consent and signing of a written informed consent form are required.
Exclusion criteria
Exclusion criteria: 1. Severe anemia (hemoglobin 150 beats/min), severe hypertension (systolic blood pressure >200 mmHg and diastolic blood pressure >110mmHg); 5. Severe lung disease, such as FEV1 35kg/m2); 7. Pregnant, breastfeeding, or planning to become pregnant during the trial; 8. Severe arrhythmia (ventricular tachycardia, ventricular fibrillation, frequent premature ventricular beats (24h dynamic cardiogram > 10,000 beats or common ECG prompts frequent premature ventricular beats), persistent atrial fibrillation, 2 degrees or 3 atrioventricular block, etc.); 9. Epilepsy; 10. Myocardial infarction, acute coronary syndrome, PCI or cardiac surgery within 90 days before screening; 11. Other researchers think that it is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local Myocardial blood flow during chemical stress; | — |
Secondary
| Measure | Time frame |
|---|---|
| Coronary Flow Reserve;Area and severity of myocardial ischemia with rest and stress;Seattle Angina Scale Score;New York Heart Function Classification;Cardiopulmonary exercise test indicators;fasting blood sugar;Insomnia Severity Index Scale; | — |
Countries
China
Contacts
Public ContactGe Junbo
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed