FindTrial
Sign In

Study of the renal tubular epithelial cells mitophagy in obstructive sleep apnea patients

Base on HIF-1a/BNIP3 signal pathway to explore the mechanism of renal tubular epithelial cellular mitophagy in intermittent hypoxia induced renal impairment

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100052164
Enrollment
Unknown
Registered
2021-10-20
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sleep apnea

Interventions

severe OSA+CPAP treatment group:None
OSA group:None
snoring group:None

Sponsors

Zhongshan Hospital, Xiamen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Snoring patients who need renal biopsy due to unexplained nephropathy such as proteinuria, hematuria, or elevated creatinine.

Exclusion criteria

Exclusion criteria: 1. Mild and moderate OSA; 2. Those with contraindications to renal biopsy; 3. Patients with chronic renal insufficiency; 4. Patients with diabetes, hypertension and heart disease.

Design outcomes

Primary

MeasureTime frame
mitophagy of renal tubular epithelial cells;polysomnography;hypoxia-inducible factor 1a;BNIP3;Biomarkers of renal function;—

Countries

China

Contacts

Public ContactZhang Xiaobin

Zhongshan Hospital, Xiamen University

zhangxiaobincn@xmu.edu.cn+86 5922590231

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026