neuromyelitis optica spectrum disorder
Conditions
Interventions
NMOSD with PTS:None
NMOSD without PTS:None
normal control group:None
Sponsors
Shanghai Jing'an District Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. NMOSD patients who meet the 2015 version of the Wingerchuk diagnostic criteria; 2. NMOSD patients with LETM onset for the first time; 3. NMOSD patients with AQP4-Ab+; 4. The vital signs are stable; 5. Voluntarily participate in this experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with epilepsy, trauma, tumors, etc., which affect the judgment of the disease; 2. Incomplete medical records; 3. Consciousness disturbance, severe cognitive or/and speech dysfunction, unable to complete the assessment; 4. Those with metal implants or other contraindications to MRI scanning; 5. Those who do not cooperate with the inspection and do not sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multimodal spinal magnetic image resonance; | — |
Secondary
| Measure | Time frame |
|---|---|
| extended disability status scale, EDSS;Penn Spasm Frequency Scale;Numerical Rating Scale;Spinal Cord Injury Health Questionnaire, SCI-HQ;American Spinal Injury Association Impairment Scale, AIS;Fugl-Meyer function assessment, FMA;Modified barthel index, MBI;Berg Balance Scale, BBS;Epworth Sleepiness Scale, ESS;Pittsburgh Sleep Quality Index, PSQI;Fatigue Scale-14, FS-14;Quality of life in patients with multiple sclerosis-54, MSQoL-54;short form 36 health survey, SF36;Hamilton Anxiety Scale, HAMA;Hamilton Depression Scale;Modified Ashworth scale, MAS;Resistance to passive movement scale, REPAS; | — |
Countries
China
Contacts
Public ContactLi Qinying
Shanghai Jing'an District Central Hospital
Outcome results
None listed