Postoperative delirium (POD)
Conditions
Interventions
Group 1:DEX + deep anesthesia
Group 2:DEX + light anesthesia
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years old, ASA classification I to III; 2. Non-cardiac major surgery (thoracic, abdominal, urology, orthopedics, spine) planned for >= 1.5 hours under general anesthesia; 3. Estimated postoperative hospital stay >= 2 days.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Left ventricular ejection fraction < 30%; 3. Sick sinus syndrome; 4. Severe sinus bradycardia (< 50 beats/min); 5. Second-degree or higher atrioventricular block without a pacemaker; 6. Alzheimer's disease, Parkinson's disease; 7. Preoperative cognitive impairment; 8. Alcohol abuse; 9. BIS monitoring cannot be applied; 10. Refusal for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients who complete the dexmedetomidine or placebo infusion and achieve the target BIS value;Incidence of POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days with POD;Pain scores at rest;Pain scores while coughing;Postoperative fentanyl consumption;Incidence of hypotension;Incidence of bradycardia;Incidence of PONV;Non-delirium complications;Postoperative days of hospital stay;Postoperative cognitive function;Mortality; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed