Cervical degenerative disease
Conditions
Interventions
Experimental group1:Intraoperative local use of glucocorticoids
Experimental group2:Postoperative intravenous glucocorticoids
Experimental group3:Intraoperative local + postoperative intravenous glucocorticoid
Control group:Intraoperative local + postoperative venous normal saline
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. According to clinical symptoms, signs and imaging manifestations (meet any one of the following: nucleus pulposus prolapse; obvious osteophyte formation; intervertebral height loss) diagnosed patients with cervical spondylosis; 3. After standardized conservative treatment, the symptoms are ineffective or the symptoms are progressively aggravated, which affects daily life and work, and requires anterior decompression surgery; 4. The operative segment is located between C3/4~C6/7; 5. NDI score greater than or equal to 30%; 6. Be able to fully comply with this agreement psychologically and physically, and cooperate with the scheduled treatment plan, fill in the form, and cooperate with follow-up visits; 7. After the patient signs the informed consent, it means that the patient has known and agreed to carry out the relevant aspects of this study.
Exclusion criteria
Exclusion criteria: 1. History of cervical spine surgery and bone fusion of adjacent segments; 2. Posterior longitudinal ligament ossification or cervical spinal stenosis, spinal fracture, severe osteoporosis or a history of bone metabolic disease; 3. Local infection and ulceration of neck skin, systemic inflammatory disease, uncontrolled diabetes, malignant tumor, active hepatitis, etc.; 4. Those with mental illness or mental disorder; 5. The general condition is poor, and the important organs suffer from serious diseases and cannot tolerate surgery; 6. Known to suffer from infectious diseases such as AIDS, syphilis, etc.; 7. Suffering from autoimmune diseases; 8. Have received daily immunosuppressive therapy for more than 1 month in the past 12 months; 9. Allergy to implant materials (PPEK or titanium alloy) or experimental drugs; 10. Severe obesity, history of drug abuse; 11. Those who have pregnancy plans during pregnancy or research; 12. Participating in other studies that may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cervical Spine Disability Index;Therapeutic Index of the Japanese Orthopaedic Association;health status questionnaire;Dysphagia classification; | — |
Countries
China
Contacts
Public ContactLiu Hao
West China Hospital, Sichuan University
Outcome results
None listed