depression
Conditions
Interventions
experiment group:conventional emotional rehabilitation training + NeuCir-VR
control group:conventional emotional rehabilitation training + VR
Sponsors
Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the DSM-5 diagnostic criteria for major depressive episode or persistent depressive disorder; 2. Aged 18 to 65 years, male or female; 3. High school education level or above, with Chinese as the mother tongue; 4. There is sufficient audiovisual level to complete the necessary examinations for the study; 5. HAMD-17 score >=17 points at the time of enrollment.
Exclusion criteria
Exclusion criteria: 1. Those with severe systemic diseases such as cardiopulmonary disease who cannot tolerate rehabilitation treatment; 2. Diagnosed who meet the diagnostic criteria for other severe mental disorders, patients with epilepsy or those with a family history of epilepsy; 3. There are influencing factors of serious systemic diseases such as diabetes and uremia. 4. According to safety guidelines, there are contraindications to TMS and MRI examinations, such as: metal foreign bodies or other implanted electronic devices in the body; 5. Hearing or visual impairment may affect assessment and virtual reality rehabilitation; 6. Use of excitatory drugs that alter the cerebral cortex (anti-epileptic drugs, sedative-hypnotic drugs, etc.); 7. Those with severe negative suicidal ideation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Neuroelectrophysiological feedback and detection;functional magnetic resonance imaging (fMRI);mini-mental state examination;daily activities ability; | — |
Countries
China
Contacts
Public ContactXu Jianguang
Shanghai University of Traditional Chinese Medicine
Outcome results
None listed