Efficacy and mechanism of Intestinal bacterial transplantation for treatment-resistant major depressive disorder

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100052128

Enrollment

Unknown

Registered

2021-10-19

Start date

2021-12-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

reatment-resistant major depressive disorder

Interventions

Experimental group:To take purified intestinal flora capsule

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. The diagnosis of treatment-resistant depression in line with DSM-V, and the Baker Depression Inventory (BDI) score >= 14 points; 2. Patient Health Questionnaire (PHQ-9) depression score >= 10 points; 3. Hamilton Depression Scale (HAMD) score >= 20; 4. Both the treatment-resistant depression and the healthy control group need to be excluded from other mental disorders by two psychiatric attending physicians through SCID interviews.

Exclusion criteria

Exclusion criteria: 1. Serious liver, kidney, heart and other important organic diseases; 2. Pregnancy; 3. Antibiotics were used 2 months before inclusion.

Design outcomes

Primary

Measure	Time frame
distribution of Intestinal flora;	—

Secondary

Measure	Time frame
lipopolysaccharide;IL-6;IL-8;TNF-a;NLRP3;CRP;Caspase-1;Neuroimage;	—

Countries

China

Contacts

Public ContactAn Cuixia

The First Hospital of Hebei Medical University

acxsunny@sina.com+86 18633889637

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026