Mild Cognitive Impairment
Conditions
Interventions
active rTMS group :repetitive transcranial magnetic stimulation (rTMS)
sham rTMS group:sham stimulation
Healthy normal group (NC):none
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The inclusion criteria for MCI group: (1) Satisfaction of the diagnostic criteria in Petersen (2004) for MCI; (2) Aged >= 60 years; (3) Disease course >= 6 months; (4) Mini-Mental State Examination (MMSE) score >= 24; (5) Montreal Cognitive Assessment (MoCA-CS) score = 60 years; (2) No cognitive complaint; (3) Mini-Mental State Examination (MMSE) score >= 24; (4) Montreal Cognitive Assessment (MoCA-CS) score <= 26; (5) 20-item Activities of Daily Living (ADL) score < 24. Both groups were matched for age, gender, and years of education.
Exclusion criteria
Exclusion criteria: The exclusion criteria for both groups were: 1. History of brain injury (e.g., cerebrovascular disease, epilepsy, Alzheimer's disease, Parkinson's disease or intracranial tumor); 2. Presence of psychiatric conditions (e.g., major depression, schizophrenia); 3. History of prolonged alcohol or drug abuse during the past 6 months; 4. Presence of severe or unstable systemic disorders (e.g., heart, liver, kidney, endocrine, hematologic or respiratory disease); 5. Communication difficulties between participants and researchers; 6. Incapability of undergoing head MRI scan; 7. Poor adherence to therapy, as assessed using the Morisky Medication Adherence Scale-8 (MMAS-8; maximum score: 8points); and 8. Participating in other clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| polysomnography (PSG) parameters;the Pittsburgh Sleep Quality Index (PSQI);Epworth sleepiness scale (ESS);insomnia severity index (ISI);Mini-Mental State Scale (MMSE);Montreal Cognitive Assessment (MoCA); | — |
Countries
China
Contacts
Public ContactYingchun Xiao
Fujian Medical University Union Hospital
Outcome results
None listed