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High-Precision transcranial direct current stimulation (HD-tdcs) improves mental symptoms and cognitive function in patients with schizophrenia:Clinical randomized controlled study

High-Precision transcranial direct current stimulation (HD-tdcs) improves mental symptoms and cognitive function in patients with schizophrenia:Clinical randomized controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100052121
Enrollment
Unknown
Registered
2021-10-19
Start date
2021-12-21
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

Experimental group1:Active HD-tDCS
Experimental group2:Sham HD-tDCS
Control group:none

Sponsors

Ningbo Kangning Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).; 2. The inclusion aged 18 to 65 years; 3. Right-handed; 4. The Ethics Committee of the Municipal Psychiatric Hospital agreed, and the subjects signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with severe physical diseases, infectious diseases and immune system diseases; 2. Patients with severe neurological disease, mental retardation or organic brain disease; 3. Pregnant or lactating women; 4. Those who received electroconvulsive therapy within the past 3 months; 5. Have a history of epileptic seizures; 6. Those who are not suitable for HD-tDCS treatment after evaluation, and those who cannot complete the collection of relevant indicators.

Design outcomes

Primary

MeasureTime frame
Positive and Negative Symptom Scale;Hamilton Depression Scale score;Hamilton Anxiety Scale Score;Reproducible neuropsychological state measure scores;Toronto Alexithymia Scale;Transcranial Magnetic Stimulation Combined with EMG Monitoring System;Near infrared functional imaging system;task state EEG;

Countries

China

Contacts

Public ContactZhou Dongsheng

Ningbo Kangning Hospital

290534201@qq.com+86 574 2630 2520

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026