Essential contribution of substrate stiffness inhibited vascularization in management of filtering bleb post-filtering surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100052083

Enrollment

Unknown

Registered

2021-10-16

Start date

2021-11-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Interventions

CXL(collagen crosslinking) group:Trabeculectomy combined collagen crosslinking

5-Fluorouracil group:Trabeculectomy combined 5-fluorouracil

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Comply with the diagnostic criteria for angle-closure glaucoma in the consensus of Chinese glaucoma experts (2018 edition); 2. Check that the angle of the patients chamber is greater than 180 degrees before surgery; 3. Anti-glaucoma drugs have been given in the outpatient clinic before the operation, but the intraocular pressure still cannot be effectively controlled.

Exclusion criteria

Exclusion criteria: 1. Complicated with other congenital eye anomalies; 2. With a history of eye surgeries other than glaucoma surgery; 3. Complicated with uncontrolled systemic diseases; 4. Could not finish the whole-course follow-up.

Design outcomes

Primary

Measure	Time frame
IOP(intraocular pressure);Vessel area;	—

Secondary

Measure	Time frame
Height of filtering bleb;Width of filtering bleb;	—

Countries

China

Contacts

Public ContactYin Xue

The First Affiliated Hospital of Soochow University

yinxuescu@suda.edu.cn+86 18913525758

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026