IgA nephropathy
Conditions
Interventions
Experimental group:Western medicine basic treatment and Wubi Shanyao Pill
Control group:Western medicine basic treatment and placebo
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years, <= 75 years; 2. Pathologically clearly diagnosed as IgA nephropathy; 3. Blood pressure is controlled at < 140/90 mmHg, and blood sugar is controlled at fasting blood glucose < 8.0 mmol/L or HbA1c < 8.0%; 4. Control of blood lipids and blood uric acid up to standard; 5. 24h urine protein quantitative is greater than 0.5 g, less than 3.5 g; 6. Renal failure risk prediction grade (eight-factor method) is medium to high risk; 7. Volunteer to participate in this trial and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who are contraindicated in the use of Wubi Shanyao Pills, including those with a history of diabetes, impaired gastrointestinal function or gastrointestinal diseases; 2. Those who have combined infections, severe cardiovascular and cerebrovascular diseases, liver insufficiency, hematopoietic diseases or malignant tumors; 3. Patients with secondary IgA nephropathy; 4. Pregnant, lactating women and women of childbearing age who are going to become pregnant; 5. Organ transplant patients including kidney transplantation; 6. Those who have been treated with hormones, immunosuppressants, or cytotoxic drugs within 3 months; 7. Those who have been treated with other Chinese Medicines and similar proprietary Chinese Medicines within half a month; 8. Those who are allergic to this drug; 9. Those who cannot cooperate, including all kinds of mental patients; 10. Participants in other clinical trials within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h proteinuria change value; | — |
Secondary
| Measure | Time frame |
|---|---|
| eGFR(estimated glomerular filtration rate) chang value;Urine protein-creatinine ratio;Urine red blood cell count;Albumin;Nutritional Assessment Form (SGA);Symptom Burden Assessment Form (LUSS); | — |
Countries
China
Contacts
Public ContactHe Qiang
Zhejiang Provincial People's Hospital
Outcome results
None listed