Treatment-resistant depression
Conditions
Interventions
Group A:Sevoflurane inhalation followed by placebo
Group B:Placebo inhalation followed by sevoflurane
Sponsors
Huzhou Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of DSM-?-TR for major depressive disorder and verified by MINI clinical interview; 2. Han Chinese; Both men and women, aged 18 to 65 years; 3. HAMD-21 >= 18 points, CGI-S >= 3 points; 4. Meet the diagnostic criteria of refractory depression: during this depression attack, the efficacy of two or more antidepressants with different structures with sufficient treatment course is poor, and the treatment of antidepressants has been ineffective for three times in the past; 5. Sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Schizophrenic affective psychosis, dysthymia or bipolar depression; any other anxiety disorder was the main diagnosis within 1 year; obsession; patients with substance abuse or dependence; personality disorder; 2. Various contraindications covered in the instructions for the use of sevoflurane; 3. Pregnant or lactating women; 4. Patients with severe or unstable heart, liver, kidney, endocrine (abnormal thyroid function), blood, autoimmune diseases and other medical diseases; Patients with epilepsy or other brain organic diseases; Increased intracranial pressure, intractable and refractory hypertension, glaucoma, etc.; 5. A history of serious attempted suicide, or a high risk of suicide, or HAMD item 3 suicide score >= 3; 6. NMDA receptor antagonists such as ketamine have been used in the past; 7. Antidepressants and psychoactive drugs were used in the first 2 weeks; 8. Those who are currently undergoing standard electrical convulsion therapy, rTMS therapy or systematic psychotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score reduction of HAMD(Hamilton Depression Scale)-21;Montgomery-Asberg Depression Rating Scale;Hamilton Anxiety Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Snaith-Hamilton Pleasure Scale;Beck Scale for Suicide Ideation;Multidimensional Fatigue Scale;Clinical Global Impression Scale; | — |
Countries
China
Contacts
Public ContactWang Shikai
Huzhou Third People's Hospital
Outcome results
None listed