Labor analgesia
Conditions
Interventions
Group 1:Ropivacaine 0.1% and Nabuphine 0.3ug/ml
Group 2:Ropivacaine 0.1% and Nabuphine 0.4ug/ml
Group 3:Ropivacaine 0.1% and Nabuphine 0.5ug/ml
Group 4:Ropivacaine 0.1% and Nabuphine 0.6ug/ml
Control group:Ropivacaine 0.1%
Sponsors
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Mature primiparity; 2. ASA I-II; 3. Single birth; 4. Spontaneous labor; 5. Aged 20-45 years; 6. Height 150-170 cm; 7. Body mass index (BMI) 24-30 kg/m^2; 8. Cervical dilation of 2-5 cm during the incubation period of labor; 9. Heart, liver, kidney, blood and other test indicators are all within the normal range.
Exclusion criteria
Exclusion criteria: 1. Important organs have primary diseases, such as nervous system diseases or neuropathy; 2. The parturient cannot cooperate with the spinal canal puncture, such as a history of mental illness; 3. There are contraindications to spinal block, such as coagulation dysfunction, infection or injury at the puncture site, uncorrected maternal hypovolemia or hypotension, increased intracranial pressure, severe spinal deformity, etc.; 4. Hypersensitivity to local anesthetics or opioids; 5. ontraindication of epidural anesthesis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 (median effective dose);Visual Analogu Scale;Modified Bromage Score;Sedation score; | — |
Countries
China
Contacts
Public ContactLiu Xiaoling
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
Outcome results
None listed