Pulmonary hypertension
Conditions
Interventions
Chronic obstructive pulmonary disease and pulmonary hypertension group:No
Sponsors
The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-80 years, and the patient has related abilities such as autonomous activities; 2. According to the 2017 edition of Guidelines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, diagnosed as chronic obstructive pulmonary disease; 3. Meet the diagnostic criteria of pulmonary hypertension: use color Doppler echocardiography of the heart to estimate the pulmonary artery pressure through the tricuspid regurgitation area, exclude the stenosis of the right ventricular outflow system, pulmonary artery systolic pressure = right ventricular systolic pressure, (pulmonary artery systolic pressure >= 40 mmHg); 4. Meet the diagnostic criteria of deficiency of lung qi and mutual resistance of phlegm and blood stasis in Traditional Chinese Medicine; 5.The baseline of 6MWD is >= 100 m and < 450 m.
Exclusion criteria
Exclusion criteria: 1. Important organs have serious primary diseases; 2. For those who have used targeted drug therapy and stopped or changed the targeted drug for less than 3 months; 3. Those with infectious diseases such as hepatitis A, hepatitis B, AIDS, tuberculosis, or active connective tissue diseases; severe infections, especially those with lung infections; 4. Patients with liver cirrhosis or portal hypertension caused by liver cirrhosis; 5. Severe bleeding or bleeding tendency; 6. Cardiac Doppler ultrasound indicates that the left ventricular ejection fraction is less than 45%; 7. Have history of bowel surgery; 8. Take antibiotics, probiotics, prebiotics, non-steroidal anti-inflammatory drugs (NSAIDs), opioids, Traditional Chinese Medicines (TCM), proton pump inhibitors (PPI) or histamine receptor antagonists within one month before sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary function;Liver function;Routine blood examination;General physical examination items;Analysis of Traditional Chinese Medicine syndrome types; | — |
Countries
China
Contacts
Public ContactWang Feiying
Hu'nan University of Traditional Chinese Medicine
Outcome results
None listed