Oral erosive lichen planus
Conditions
Interventions
Experimental group:Topical use of freeze-dried powder containing Nr-CWS
Control group:0.1% triamcinolone acetonide oral ointment for topical use
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as erosive oral lichen planus based on medical history, clinical manifestations and pathology; 2. Erosion area <= 1 cm^2; 3. Aged 18-75 years, no relevant treatment drugs were used 1 month before the onset; 4. No serious systemic diseases such as diabetes; 5. Understand the whole process of observation and research, participate voluntarily and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with other confirmed oral mucosal diseases; 2. Patients suffering from major infectious diseases, precancerous lesions or tumors in other parts; 3. Severe periodontitis (periodontal pocket > 6 mm, attachment loss >= 5 mm, alveolar bone resorption exceeds 2/3 of the root length); 4. Patients who have received local or systemic immunologic therapy within 1 month; 5. Some drugs or silver amalgam fillings may cause lichen-like reactions; 6. People with allergies and history of allergies to drugs or food; 7. Women during pregnancy and lactation; 8. Those who cannot follow the doctor's prescription or have incomplete test records, liver and kidney function test > 1.2 times the normal value range, which affects the judgment of curative effect.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale; | — |
Countries
China
Contacts
Public ContactHua Hong
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed