Acute ischemic stroke
Conditions
Interventions
Experimental group:rtPA(recombinant tissue plasminogenactivator) and tirofiban
Sponsors
The First Affiliated Hospital of Bengbu Medical College
Eligibility
Sex/Gender
All
Age
45 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. A clinical diagnosis of acute ischemic stroke; 2. CT or MRI ruling out intracranial hemorrhage; 3. Eligible for intravenous thrombolysis with alteplase (within 4.5 hours after symptom onset); 4. NIHSS > 2; 5. Aged 45 years or older; 6. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Prestroke mRS > 1; 2. Sustained hypertension (blood pressure: >220/>120 mmHg); 3. Renal failure (creatinine > 200 umol/L); 4. Cirrhosis; 5. Severe dementia or psychosis; 6. Brain tumor or other significant non-ischemic brain lesion on brain CT scan; 7. Chronic rheumatic heart disease; 8. Participation in another clinical trial; 9. Planning pregnancy during the course of the trial or having a positive urine pregnancy test before randomization; 10. Acute myocardial infarction or unstable angina pectoris in two weeks, severe heart failure, aortic dissection, and deep coma; 11. Use of anticoagulant with INR exceeding 1.7; 12. Treatment with direct thrombin or factor X inhibitors; 13. Treatment with heparin (APTT exceeds the upper limit of normal value) in the previous 48 hours; 14. NIHSS score > 22.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin scale score score (%); | — |
Secondary
| Measure | Time frame |
|---|---|
| Barthel Index >= 95 points (%);National Institute of Health stroke scale 0-1 (%);EuroQol Five Dimensions Questionnaire score; | — |
Countries
China
Contacts
Public ContactZhou Huadong
The First Affliated Hospital of Bengbu Medical College
Outcome results
None listed