Pulmonary ground glass nodular disease (GGN)
Conditions
Interventions
Therapy group:Infusion of autologous NK cells (natural killer cells)
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in clinical trials and sign informed consent; 2. Aged 20-70 years; 3. GGN positive; positivity was defined as having at least one noncalcified solid or partially solid nodule >= 5 mm in diameter, or at least one nonsolid nodule >= 8 mm in diameter; 4. It is not applicable to subjects receiving local treatment (including intervention, radiofrequency ablation, etc.) and other treatments; 5. Routine blood test reached the following indexes: lymphocyte count >= 0.4 x 10^9/L, neutrophil >= 1.0 x 10^9/L, platelet >= 60 x 10^9/L, hemoglobin >= 60g/L; 6. Liver and kidney function: ALT (Alanine Aminotransferase) or AST (Aspartate Aminotransferase) index 50 mL /min; total bilirubin = 50%, no serious arrhythmia; 9. Within 2 months, no anti-inflammatory drugs, immune-enhancing hormones or drugs have been taken or completely recovered from inflammation.
Exclusion criteria
Exclusion criteria: 1. Subjects who have a history of allergy to any component of the study drug; 2. Screening subjects enrolled in another interventional clinical study within 3 weeks prior; 3. Patients who developed other primary malignancies within the past 3 years; 4. Patients who have had an organ transplant or previous cell transplant in the past 20 years; 5. Active infections requiring treatment; 6. Active or previously documented autoimmune or inflammatory diseases; 7. Patients with any form of primary or acquired immune deficiency; 8. Patients with hereditary or acquired coagulation disorders; 9. Central nervous system diseases with clinical significance; 10. The presence of a serious mental illness that prevents full informed consent; 11. Any participant deemed unfit to participate in the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Computed tomography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunity indicators; | — |
Countries
China
Contacts
Public ContactShi Hui
Shanghai Tenth People's Hospital
Outcome results
None listed