Nephrotic syndrome
Conditions
Interventions
Primary nephrotic syndrome:No
Sponsors
The Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 3 to 18 years(inclusive); 2. Fulfilled the International Study of Kidney Disease in Children (ISKDC) criteria for PNS who were new-onset and not treated with glucocorticoids or other immunosuppressive agents prior to this study; 3. Normal estimated glomerular filtration rate (eGFR > 90 mL/min/1.73m^2) as calculated by the Schwartz formula; 4. Patients or their parents can communicate well with the doctor; 5. Written informed consent was obtained from the patients and their parents.
Exclusion criteria
Exclusion criteria: 1. Steroid resistant nephrotic syndrome; 2. With a family history of nephrotic syndrome, chronic glomerulonephritis, or uremia; 3. With other autoimmune diseases or primary immunodeficiency or tumors; 4. Those who have not completed the clinical research according to the clinical trial protocol; 5. The researcher judged that the patients condition is not suitable for participating in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucocorticoid exposure over the study interval; | — |
Secondary
| Measure | Time frame |
|---|---|
| FRNS(Frequently Relapsing Nephrotic Syndrome);Adverse events;Time to first relapse;Recurrence-free survival rate in the first year;Number of relapses;SDNS(Steroid-Dependent Nephrotic Syndrome); | — |
Countries
China
Contacts
Public ContactYang Guoping, Li Zhihui
The Third Xiangya Hospital, Central South University
Outcome results
None listed