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Population pharmacokinetics and pharmacodynamics of rocuronium in obese patients

Population pharmacokinetics and pharmacodynamics of rocuronium in obese patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100052002
Enrollment
Unknown
Registered
2021-10-12
Start date
2021-10-12
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Sponsors

The First Affiliated Hospital of University of Science and Technology of China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 60 years; 2. Surgery is required under general anesthesia; 3. American Society of Anesthesiologists (ASA) grade I -II; 4. Be able to communicate well with researchers and comply with the requirements of the whole experiment; 5. Understand the purpose of the study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Known allergy to any narcotic or ingredient in the programme; 2. Communication barriers or inability to cooperate; 3. Secondary surgery or emergency surgery; 4. Pregnancy; 5. Gastrointestinal obstruction; 6. Acute attack or severe bronchial asthma; 7. Neuromuscular diseases; 8. Abnormal liver and kidney function; 9. Abnormal ECG; 10. White blood cells or red blood cells indicated by urine routine examination; 11. Have a history of HIV, syphilis, infectious hepatitis and other infectious diseases; 12. Have mental diseases, unable to cooperate with research; 13. Taking drugs that affect neuromuscular transmission; 14. Have a history of alcohol abuse or illicit drug abuse within 2 years; 15. Have a history of blood donation or receiving blood transfusion in the past three months; 16. Participated in other clinical trials in the last three months.

Design outcomes

Primary

MeasureTime frame
Blood level of rocuronium;T4/T1 proportion;Onset time;Time of duration;Recovery index;

Secondary

MeasureTime frame
Wake-up time;Extubation time;

Countries

China

Contacts

Public ContactHou Guanfeng

The First Affiliated Hospital of University of Science and Technology of China

35340796@qq.com+86 13485701368

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026