Minimally invasive root canal therapy system based on erbium laser activated irrigation in periapical periodontitis: a non-inferiority, randomized controlled clinical trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100051999

Enrollment

Unknown

Registered

2021-10-12

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periapical periodontitis

Interventions

Experimental group:Root canal therapy under minimally invasive mechanical preparation

Control group:Root canal treatment under conventional mechanical preparation

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Outpatient diagnosis of pulpitis patients; 2.The four walls of the affected tooth are intact or single-wall defect; 3.Aged 18 to 60 years, gender is not limited; 4.Good oral hygiene; 5.Informed consent can be signed.

Exclusion criteria

Exclusion criteria: 1.Serious systemic diseases (such as uncontrolled diabetes, cardiovascular diseases, immune disorders, blood diseases, etc.); 2.Pregnant or lactating women; 3.Patients with mental illness or a history of mental illness; 4.Patients with infectious diseases (such as hepatitis, syphilis, AIDS patients, etc.); 5.Patients with head and neck tumors, or after radiotherapy of tumor head and neck; 6.Patients who have taken antibiotics in the past three months; 7.Poor oral hygiene, or patients with moderate to severe periodontitis; 8.Patients with abnormal salivary gland function; 9.Patients with temporomandibular joint disorder; 10.Patients with night grinding or serious abnormal occlusion; 11.Patients with acid erosion and severe caries; 12.Patients with more than one wall defect after the target tooth has been cleaned of decayed matter or patients who need post-core repair; 13.Cracked teeth; 14.The target tooth has undergone endodontic treatment; 15.At present, the patients with the defect located more than 1mm below the gingival after the tooth has been cleaned of decay; 16.Patients whose distance between the top and bottom of the pulp chamber is less than 6mm at present.

Design outcomes

Primary

Measure	Time frame
Periapical index;	—

Secondary

Measure	Time frame
Verbal rating scale;Visual self-rating;Patient self-score;	—

Countries

China

Contacts

Public ContactZhao Jizhi

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

zhaojizhi@126.com+86 18612671920

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026