To observe the effect of scopolamine on patients with high risk of anxiety and depression during perioperative period and to explore its new drug targets

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100051997

Enrollment

Unknown

Registered

2021-10-12

Start date

2021-11-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative anxiety and depression

Interventions

Experimental group:Scopolamine 0.3 mg before anesthesia induction

Control group:Intravenous injection of equal volume of saline before anesthesia induction

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age range: aged 18 to 65 years; 2.Patients undergoing elective abdominal surgery; 3.Clear consciousness, no abnormal mentality, junior high school education level or above, can independently and accurately complete the assessment of the scale; 4.American Society of Anesthesiologists (ASA) classification I-III; 5.Patients with mild, moderate and severe anxiety and depression were evaluated by the Hospital Anxiety and Depression Scale (HADS); 6.Agree to include clinical observers.

Exclusion criteria

Exclusion criteria: 1.Long-term use of glucocorticoids, interferon and other immunomodulatory drugs; 2.Patients diagnosed with anxiety, depression, and schizophrenia in the past; those who are taking related drugs or who have undergone electroconvulsive therapy within one month during the onset of severe mental illness; 3.Patients with heart, brain, kidney, liver and other organ failure; 4.Patients who are contraindicated in the use of scopolamine, such as glaucoma, severe arrhythmia, and tachycardia; 5.Major intraoperative bleeding (blood volume >= 30% of systemic blood volume) is expected to occur, and vital signs are unstable; 6.A history of asthma and bronchospasm; 7.BMI>30; pregnant and lactating women; 8.Preoperative hypertension without drug control, severe hypertension: systolic blood pressure higher than 180mmhg.

Design outcomes

Primary

Measure	Time frame
Hospital Anxiety and depression scale;pittsburgh sleep quality index scale;Preoperative Amsterdam preoperative anxiety and information scale;	—

Secondary

Measure	Time frame
Immune inflammatory index ;Serum cortisol content and circadian rhythm change rate;	—

Countries

China

Contacts

Public ContactShu Haihua

Guangdong Provincial People's Hospital

shuhaihua@hotmail.com+86 13427536899

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026