acute myocardial infarction
Conditions
Interventions
Experimental group1:Start taking sacubitril valsartan within 2 hours after PCI
Experimental group2:Start taking sacubitril valsartan within 3-7 days after PCI
Sponsors
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.At least 18 years old; 2.Diagnosis of AMI according to the accepted definition of myocardial infarction; 3.AMI patients who received PCI within 24 hours of onset can be treated with sacubitril valsartan according to the judgment of the clinician; 4.Voluntarily participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Cardiogenic shock has occurred within 24 hours; 2.The patient has a known history of angioedema; 3.Known or suspected bilateral renal artery stenosis; 4.When screening, adopt the simplified modified diet for kidney disease (MDRD) formula to calculate eGFR 5.2 mmol/L during screening; 6.Have a history of allergy to sacubitril valsartan or neprilysin inhibitors or other drugs of similar chemical categories; 7.History of malignant tumor of any organ system in the past 3 years, and the life expectancy is less than 1 year; 8.Vulnerable groups, including mentally ill people, critically ill patients, pregnant women, minors, people with cognitive impairment, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular end diastolic volume index;Left ventricular end systolic volume index;Left atrial volume index;Ratio of peak E to peak A;Left ventricular end diastolic volume;Left ventricular end systolic volume;Left ventricular ejection fraction;Cardiothoracic ratio;Amino terminal brain natriuretic peptide progen; | — |
Countries
China
Contacts
Public ContactFu Guosheng
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed