Perioperative anxiety and depression
Conditions
Interventions
Experimental group:Preoperative injection of esketamine 0.25mg/kg
Control group:Injection of normal saline
Sponsors
ZhuJiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged 20 to 60 years; 2.Patients with elective laparoscopic gallbladder surgery; 3.Clear consciousness, no abnormal mentality, junior high school education level or above, can independently and accurately complete the assessment of the scale; 4.American Society of Anesthesiologists (ASA) classification I-II; 5.Patients with mild to moderate anxiety and depression with a score of 11-20 on the Amsterdam Preoperative Anxiety and Information Scale (APAIS) before surgery; 6.Agree to include clinical observers.
Exclusion criteria
Exclusion criteria: 1.Patients diagnosed with anxiety disorder, depression and schizophrenia in the past; 2.Patients with APAIS score less than 10 or greater than 20 3.Patients with heart, brain, kidney, liver and other organ failure; 4.Severe language, hearing impairment and mental retardation; 5.Major intraoperative bleeding (blood volume >= 30% of systemic blood volume) is expected to occur, and vital signs are unstable; 6.Past history of immune system diseases; 7.Allergic reaction to esketamine; 8.Preoperative hypertension without drug control, severe hypertension: systolic blood pressure higher than 180mmhg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital anxiety and depression scale;Anxiety Visual Analog Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune inflammatory index;Cell CD4 + / CD8 + ratio;Preoperative Amsterdam preoperative anxiety and information scale; | — |
Countries
China
Contacts
Public ContactLiu Zhongjie
ZhuJiang Hospital of Southern Medical University
Outcome results
None listed