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Effect of left atrial appendage electrical isolation on the efficacy and safety of catheter ablation for persistent atrial fibrillation: a prospective, randomized controlled, multicenter clinical study

Effect of left atrial appendage electrical isolation on the efficacy and safety of catheter ablation for persistent atrial fibrillation: a prospective, randomized controlled, multicenter clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100051966
Enrollment
Unknown
Registered
2021-10-10
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation

Interventions

Experimental group:Electrical isolation of left atrial appendage
Control group:None

Sponsors

The First Affiliated Hospital of China University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years old; 2.For symptomatic PeAF, catheter ablation + LAAC (one-stop) operation is planned; 3.The patient/legal representative can understand or abide by the agreement, sign informed consent and complete postoperative follow-up; 4.Life expectancy >=12 months.

Exclusion criteria

Exclusion criteria: 1.Paroxysmal atrial fibrillation; 2.Pregnancy; 3.Anticoagulation contraindications; 4.Thrombosis in the left atrium or left atrial appendage; 5.Acute stage of malignant tumor; 6.Have diseases that may cause atrial fibrillation, such as: thyroid dysfunction, acute alcoholism, cardiac events (myocardial infarction, percutaneous coronary intervention, valve or coronary artery bypass surgery, etc.) within the first 3 months; 7.History of heart transplantation; 8.Currently participating in another study.

Design outcomes

Primary

MeasureTime frame
Effectiveness;Security;Atrial fibrillation;Atrial flutter;Atrial tachycardia;Transesophageal echocardiography;Head computed tomography;Transcatheter ablation;Left atrial appendage occlusion;Holter electrocardiogram;

Countries

China

Contacts

Public ContactLuo Jianfeng

The First Affiliated Hospital of China University of Science and Technology

luojianfengah@163.com+86 15056013064

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026