Early esophageal cancer
Conditions
Interventions
Experimental group :PRP was injected into the residual submucosa immediately after ESD, and acid-suppressing therapy was administered orally with prednyl acetate and PROTON pump inhibitor PPI for 8 w
Control group:Triamcinolone acetonide was injected into the residual submucosa immediately after ESD, and acid-suppressing therapy was administered orally with prednisoll acetate and PROTON pump inhib
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.It is considered to be early esophageal cancer by pathological examination or endoscopy, and the lesion area accounts for >=75% of the surrounding mucosa; the wound mucosal defect after ESD is >=75%; 2.Aged 18 to 80 years; 3.Good treatment compliance, can complete the follow-up; 4.No distant metastasis and surrounding invasion confirmed by imaging; 5.Patients and their families gave informed consent to this study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with other malignant tumors or other esophageal diseases; 2.Complicated with organ dysfunction; 3.Poorly controlled diabetes, necrosis of the femoral head, peptic ulcer and tuberculosis; 4.Pregnant or lactating women; 5.Patients with contraindications to endoscopic surgery. Long-term oral administration of systemic cortisol hormones and anticoagulant and antiplatelet drugs.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative complications;Glucocorticoid-related adverse events; | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative stenosis;Stooler score;Times of expansions;Duration of symptom remission; | — |
Countries
China
Contacts
Public ContactShi Lei
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed