A prospective clinical trial study on accurate assessment of patent foramen ovale and right-to-left shunt with contrast-enhanced acoustic echocardiography of the right heart

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100051962

Enrollment

Unknown

Registered

2021-10-10

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Foramen ovale is not closed and shunts right to left

Interventions

Gold Standard:Transesophageal Right Heart Acoustic Contrast-enhanced Contrast.

Index test:The&#32

presence&#32

or&#32

absence&#32

of&#32

microbubbles&#32

in&#32

the&#32

right&#32

heart&#32

after&#32

left&#32

is&#32

cloudy.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients with suspected PFO such as cryptogenic stroke, migraine headaches, TIA attacks, etc.; 2.Sign the informed consent form; 3.Able to cooperate with effective Valsalva motor.

Exclusion criteria

Exclusion criteria: 1.Patients with other congenital heart diseases such as atrial septal defect, ventricular septal defect and other intracardiac shunts; 2.Patients with known pulmonary arteriovenous fistula; 3.Patients with atrial fibrillation or other reasons that cause the left atrium to enlarge and the pressure of the left atrium to increase; 4.Pregnant and lactating women; 5.Patients with other serious cardiovascular and cerebrovascular diseases.

Design outcomes

Primary

Measure	Time frame
Right heart microbubbles;	—

Countries

China

Contacts

Public ContactXiong Huahua

Shenzhen Second People's Hospital

dennis8710@163.com+86 13682419816

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026