SARS-CoV-2 vaccine
Conditions
Interventions
PLWH group vs. Healthy control group:Nil
Sponsors
Department of Infectious Diseases, Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.PLWH group: (1) Aged above 18 years old; (2) Outpatient department of Nanfang Hospital from January 21, 2019 to September 21, 2019; (3) The diagnosis of HIV was based on the Guidance of Chinese AIDS Diagnosis and Treatment Guidelines (2018 edition); (4) At the time of visit, two doses of SARS-COV-2 inactivated vaccine had been given for more than 5 days; (5) Agreed to join the study and signed the informed consent. 2.Healthy control group: (1) Aged above 18 years old; (2) Outpatient department of Nanfang Hospital from January 21, 2019 to September 21, 2019; (3) HIV antibody negative; (4) At the time of visit, two doses of SARS-COV-2 inactivated vaccine had been given for more than 5 days; (5) Agreed to join the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Individuals with presence of fever, cough, and other symptoms of upper respiratory tract infection 1 month prior; 2. Individuals treated with oral hormones or immunosuppressive drugs; 3. Individuals with previous infection with SARS-CoV-2; 4. Individuals that had received plasma replacement therapy recently; 5. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| age;sex;high;weight;therapy duration;CD4 counts;CD8 counts;HIV RNA level;SARS-CoV-2 IgG level;SARS-CoV-2 IgM level;Neutralizing antibody; | — |
Secondary
| Measure | Time frame |
|---|---|
| alanine aminotransferase;aspartate aminotransferase;albumin;globulin;platelets;lymphocytes;syphilis antibody;tuberculosis;hepatitis B surface antigen; | — |
Countries
China
Contacts
Public ContactJie Peng
Department of Infectious Diseases, Nanfang Hospital, Southern Medical University
Outcome results
None listed