Treatment of knee osteoarthritis with ozone injection guided by ultrasound at different frequencies

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100051929

Enrollment

Unknown

Registered

2021-10-09

Start date

2020-01-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gonarthrosis

Interventions

Group 1:B-ultrasound-guided injection of medical ozone

Group 2:conventional injection of medical ozone

Group 3:conventional injection of triamcinolone acetonide

Eligibility

Sex/Gender

All

Age

40 Years to 68 Years

Inclusion criteria

Inclusion criteria: The experimental subjects were 90 patients with knee osteoarthritis, 1. Meeting the diagnostic criteria of knee osteoarthritis developed by The American College of Rheumatology (ACR); 2. Knee Kallgren-Lawrence imaging grading criteria: Grade I, II (mild); 3. Signing informed consent; 4. Treatment and follow-up can be completed according to the treatment plan.

Exclusion criteria

Exclusion criteria: 1. Patients with rheumatoid arthritis, gout, diabetes, blood diseases, severe cardiovascular diseases and infected persons; 2. Taking anticoagulant, antithrombotic and antiplatelet drugs and non-steroidal anti-inflammatory drugs; 3. Hemoglobin < 110g/L, platelet count < 150 x 10^9/L; 4. Meniscus defect; 5. Patients with serious basic diseases, such as severe cardiopulmonary diseases and abnormal coagulation function.

Design outcomes

Primary

Measure	Time frame
VAS score;Lysholm knee score;WOMACscore;	—

Countries

China

Contacts

Public ContactZhiyang Cai

Xiangya Changde Hospital

caitoy@163.com+86 17607369646

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026