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Optimizing cerebral blood flow and strengthening brain protection to improve brain function of patients with hypothermic circulatory arrest

Optimizing cerebral blood flow and strengthening brain protection to improve brain function of patients with hypothermic circulatory arrest

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100051927
Enrollment
Unknown
Registered
2021-10-09
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic dissection

Interventions

Sponsors

Cardiovascular Hospital of Xiamen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Diagnose aortic dissection via aortic computed tomography angiography; 2. Age >= 18 years old; 3. Perform aortic arch reconstruction surgery under HCA+SACP; 4. Sign the informed consent form, and the process of obtaining the informed consent form meets the requirements of relevant regulations; 5. After HCA+SACP, complete ONSD and TCD/TCCD examinations within 6 hours after admission to the ICU.

Exclusion criteria

Exclusion criteria: 1. Preoperative coma; 2. Head CT suggests that there is a new cerebrovascular accident, including stroke, subarachnoid hemorrhage, etc.; 3. ONSD examination is not suitable for eye trauma or past eye diseases; 4. The sound through the skull acoustic window is poor, and TCD/TCD examination cannot be performed; 5. Neurological diseases that affect cognition such as dementia and Alzheimer's disease; 6. Have a history of schizophrenia, depression, mania and other mental illnesses; 7. Participate in other psychosocial intervention measures during the same period; 8. Impairment of verbal communication, unable to communicate; 9. Suffered from severe liver failure and/or hepatic encephalopathy before surgery; 10. Patients with severe renal insufficiency and/or renal encephalopathy before surgery; 11. Refuse to join the group or exit during the period.

Design outcomes

Primary

MeasureTime frame
Incidence of delirium;Severity of delirium;

Secondary

MeasureTime frame
Incidence of symptomatic epilepsy;Mechanical ventilation time;The incidence of ventilator-associated pneumonia;Length of hospital stay;Length of stay in intensive care unit;

Countries

China

Contacts

Public ContactWang Juxiang

Cardiovascular Hospital of Xiamen University

xmwjx2012@126.com+86 15359359336

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026