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To compare the effects of different inhaled oxygen concentrations on postoperative pulmonary complications in patients undergoing open surgery under the pulmonary protective ventilation strategy guided by driving pressure

To compare the effects of different inhaled oxygen concentrations on postoperative pulmonary complications in patients undergoing open surgery under the pulmonary protective ventilation strategy guided by driving pressure: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100051922
Enrollment
Unknown
Registered
2021-10-09
Start date
2021-10-11
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pulmonary complications

Interventions

Experimental group 1:The intraoperative oxygen concentration was 30%
Experimental group 2:The intraoperative oxygen concentration was 80%

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=18 years old; 2.ASA: grade I-III; 3.Expected operation time >= 2 hours; 4.Elective laparotomy with endotracheal intubation under general anesthesia; 5.The informed consent has been signed.

Exclusion criteria

Exclusion criteria: 1.Plan to undergo laparoscopic surgery, open surgery combined with intrathoracic surgery, lateral or prone position surgery; 2.Pregnant and lactating women; 3.BMI>35Kg/m^2; 4.Acute lung injury or acute respiratory distress syndrome within 3 months before surgery; 5.History of severe chronic obstructive pulmonary disease (GOLD grade III-IV or non-invasive ventilation or oxygen therapy at home); 6.Combined with heart failure grades III-IV (New York Heart Association Heart Failure Grading Criteria), severe kidney or liver disease; 7.Chest imaging suggests pneumothorax or giant pulmonary bullae; 8.Patients who need reoperation or need ventilation and circulation support after surgery; 9.Participated in other clinical trials.

Design outcomes

Primary

MeasureTime frame
Postoperative pulmonary complications;—

Secondary

MeasureTime frame
Postoperative pulmonary complications;The severity of postoperative pulmonary complications was graded;Oxygen saturation while inhaling air;Surgical site infection;Sepsis;Septic shock;Postoperative nausea and vomiting;Anastomosis dehiscence;Postoperative reintubation;Postoperative unplanned transfer to intensive care unit;Hospital stays;Mortality within 30 days;—

Countries

China

Contacts

Public ContactYu Hai

West China Hospital, Sichuan University

yuhaishan117@yahoo.com+86 18980601548

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026