depression
Conditions
Interventions
Experimental group 1:Esketamine
Experimental group 2:Propofol
Experimental group 3:Esketamine+propofol
Control group:None
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Depression: 1.Evaluated by the Structured Clinical Interview of the DSM-IV (SCID) for DSM-IV Axis I Disorders, meeting the DSM-IV diagnostic criteria for depression, and meeting the TRD criteria (sufficient quantity and sufficient course of treatment with at least two antidepressants with different mechanisms of action are ineffective); 2.HAMD-17 total score >= 17 points; 3.Aged 18 to 65 years, no gender restrictions, at least 6 years of education; 4.Han nationality, right-handed; 5.Understand the research content and sign the informed consent. Normal control group: I or my relatives of two generations and three generations did not meet any of the diagnostic criteria for mental disorders in DSM-IV before or at present, and had no blood relationship with the two groups of patients; The inclusion criteria for TRD patients were 3~5.
Exclusion criteria
Exclusion criteria: Depression: 1.Suffering from other severe mental disorders that meet the diagnostic criteria of DSM-IV, including schizophrenia, schizoaffective disorder, bipolar disorder, etc.; 2.History of serious physical or cerebral organic disease, history of craniocerebral trauma and history of epilepsy; 3.History of drug, alcohol or other psychoactive substance abuse; 4.Patients with metal in the body, such as pacemakers or intracerebral electrodes; 5.Past history of allergy to anesthetics; 6.Women who are pregnant or breastfeeding or planning to become pregnant; 7.Patients with contraindications to magnetic resonance imaging scanning or factors that affect imaging quality, such as cardiac pacemakers, cardiovascular and cerebrovascular metal stents, cochlear implants, metal dentures, etc.; 8.The doctor in charge considers that it is not suitable for ECT treatment from the perspective of treatment. Normal control group: Same as TRD patient group. Their age, sex, and years of education were matched to the TRD patient group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| General information assessment;Cognitive function;Assessment scale; | — |
Countries
China
Contacts
Public ContactZheng Wei
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed