Ankylosing spondylitis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Low back pain and stiffness for more than 3 months, improved only with exercise, but not at rest; 2.The sagittal and coronal motion of the lumbar spine is limited; 3.The chest activity is lower than that of healthy people of the same age and gender; 4.Bilateral sacral arthritis reaches or exceeds grade I or unilateral sacral osteoarthritis grades I-V.
Exclusion criteria
Exclusion criteria: 1.Patients with high methotrexate allergy; 2.Renal insufficiency; 3.Active gastric and duodenal ulcers; 4.Moderate and severe heart failure; 5.Infection, 6.Low blood volume; 7.Coagulation, or mental disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of inflammatory factors associated with ankylosing spondylitis;Changes in pathological indicators; | — |
Countries
China
Contacts
The Affiliated Hospital of Shandong Academy of Medical Sciences