The relationship between corneal epithelial changes observed by IVCM and tear cytokines of ocular chronic graft-versus-host disease(GVHD)

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100051883

Enrollment

Unknown

Registered

2021-10-09

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graft-versus-host disease

Interventions

GVHD group:None

Control group:None

Eligibility

Sex/Gender

All

Age

5 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed as ocular chronic graft-versus-host disease; 2. First visit to a doctor; 3. Not receiving local immunosuppressive therapy.

Exclusion criteria

Exclusion criteria: 1. Eye surgery within the past six months; 2. Other eye diseases (autoimmune diseases, glaucoma, infection, retinopathy, allergy, cataract eye trauma, etc.); 3. Unable to undergo confocal microscopy due to poor physical and/or mental condition; 4. Incomplete medical records; 5. Unable to follow up.

Design outcomes

Primary

Measure	Time frame
Visual acuity;Intraocular pressure;Ocular Surface Disease Index;Corneal fluorescein staining;Tear Break-up Time;Schirmer's test;Concentration of cytokines in tear;Intravital confocal microscopy;	—

Countries

China

Contacts

Public ContactHong Jing

Peking University Third Hospital

hongjing1964@sina.com+86 13910573646

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026