Atrial Fibrillation
Conditions
Interventions
Experimental group:Left atrial appendage closure + radiofrequency ablation
Sponsors
Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Non-valvular atrial fibrillation (NVAF) for which symptomatic antiarrhythmic drugs are ineffective; 3. One or more CHA2DS2-VASc risk factors; hypertension, abnormal liver and kidney function, stroke, bleeding history or susceptibility, unstable international normalized ratio, age 65+, and drug or alcohol intake; 4. High bleeding risk score >= 3 or previous major bleeding event; 5. LAAO therapy is preferred as an alternative to long-term oral anticoagulants.
Exclusion criteria
Exclusion criteria: Development of left atrial thrombus, significant valvular heart disease, LA enlargement (>=55 mm) and additional ablation or CFAE ablation strategies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| atrial natriuretic peptide;brain natriuretic peptide ;heart rate;QT interphase length;the volume of left atrial;the volume of left atrial appendage; | — |
Countries
China
Contacts
Public ContactLi Yihan
Shandong University
Outcome results
None listed