vascular cognitive impairment
Conditions
Interventions
Vascular cognitive impairment patient group:None
Cerebrovascular disease without cognitive impairment patients group:None
Sponsors
Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. VCI patient group: (1) Aged 60-85 years, gender is not limited; (2) Meet the above-mentioned VCI diagnostic criteria; (3) Patients with mild or moderate disease, with a score between 10 and 24 on the Mini-Mental State Examination (MMSE); (4) Meet one of the above diagnostic criteria for Qi deficiency and blood stasis syndrome, kidney essence deficiency syndrome, and phlegm blocking orifice syndrome; (5) The presence of cerebrovascular disease confirmed by head CT or MRI scan; (6) Modified Hachinski ischemia scale (modified Hachinski ischemic scale, mHIS) total score >= 4; (7) Patients agree to participate in this trial, and they or their legal guardians and caregivers sign the informed consent form before the trial. 2. Patients with cerebrovascular disease without cognitive impairment: (1) Aged 60-85 years, gender is not limited; (2) There is a history of cerebrovascular disease, but does not meet the diagnosis of the above VCI; (3) Meet one of the above diagnostic criteria for Qi deficiency and blood stasis syndrome, kidney essence deficiency syndrome, and phlegm blocking orifice syndrome; (4) The presence of cerebrovascular disease confirmed by head CT or MRI scan; (5) The total score of the modified Hachinski ischemia scale is less than 4; (6) The patients agree to participate in this trial, and they or their legal guardians and caregivers sign the informed consent form before the trial.
Exclusion criteria
Exclusion criteria: 1. VCI patient group: (1) Patients with dementia caused by other causes, including Alzheimer's disease, Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, epilepsy, chronic subdural hematoma and multiple sclerosis, history of severe head trauma with persistent neurological deficits or known structural brain abnormalities; (2) Those with severe neurological deficits who cannot complete the examination, such as hand hemiplegia, various aphasia, audio-visual impairment, etc.; (3) Thyroid disease, vitamin B12 or folic acid deficiency, severe anemia or malnutrition, severe heart, liver, lung, kidney and other organ diseases that affect the function of the central nervous system; (4) Severe mental illness (such as depression, schizophrenia) and epilepsy; (5) Participated in other clinical trials within 3 months before the start of this study. 2. Patients with cerebrovascular disease without cognitive impairment: (1) There are serious circulatory, respiratory, urinary, digestive, hematopoietic system diseases (such as unstable angina pectoris, uncontrolled asthma, active gastric bleeding, etc.) and cancer; (2) Severe mental illness (such as depression, schizophrenia) and epilepsy; (3) Participated in other clinical trials within 3 months before the start of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exosomal miRNA associated with neurovascular units; | — |
Countries
China
Contacts
Public ContactSun Linjuan
Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences
Outcome results
None listed