Non-alcoholic fatty liver disease (NAFLD)
Conditions
Interventions
NAFLD group:gastroscopy
Healthy control group:gastroscopy
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. NAFLD group: (1) Aged 18-75 years; (2) Histology or imaging studies suggest ''fatty liver'', without excessive alcohol consumption (men > 30g/day; women > 20g/day), viral hepatitis, autoimmune liver disease, drug-induced liver disease, hepatolenticular degeneration, etc. ; (3) No organic gastrointestinal lesions, such as inflammation, ulcers, tumors, etc. (including esophagitis, gastritis, duodenitis, peptic ulcer, celiac disease, inflammatory bowel disease, etc.); (4) Not taking antibiotics, probiotics, prebiotics, synbiotics, non-steroidal anti-inflammatory drugs (aspirin), etc. in the past month. 2. Healthy control group: (1) Aged 18-75 years; (2) Imaging indicates no hepatic steatosis; (3) No organic gastrointestinal lesions, such as inflammation, ulcers, tumors, etc. (including esophagitis, gastritis, duodenitis, peptic ulcer, celiac disease, inflammatory bowel disease, etc.); (4) Not taking antibiotics, probiotics, prebiotics, synbiotics, non-steroidal anti-inflammatory drugs (aspirin), etc. in the past month.
Exclusion criteria
Exclusion criteria: 1. History of tumor within five years; 2. Coagulation disorders, or taking anticoagulant drugs within one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duodenal mucosal microbiome;Gastric mucosal microbiome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Blood biochemical indicators;Body mass index; | — |
Countries
China
Contacts
Public ContactJi Feng
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed