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A randomized controlled clinical trial of platelet-rich plasma in the treatment of anastomotic stricture after radical resection of esophageal cancer

A randomized controlled clinical trial of platelet-rich plasma in the treatment of anastomotic stricture after radical resection of esophageal cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100051846
Enrollment
Unknown
Registered
2021-10-07
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

Control group:Routine endoscopic rod dilation
Experimental group:Conventional endoscopic rod dilation + postoperative anastomotic injection of PRP

Sponsors

The Affiliated Hospital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The patient has subjective symptoms of dysphagia after radical resection of esophageal cancer, such as only liquid diet; 2. Aged 18-80 years; 3. There is no contraindication for endoscopic treatment, and ordinary gastroscope cannot pass through the stenosis smoothly; 4. No local recurrence or peripheral invasion confirmed by imaging; 5. Patients and their families gave informed consent to this study and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with other malignant tumors or other esophageal diseases; 2. Complicated with organ dysfunction; 3. Combined with anastomotic leakage; 4. Patients with recurrence of anastomotic tumor; 5. Those with poor treatment compliance and unable to complete the follow-up review; 6. Pregnant or lactating patients.

Design outcomes

Primary

MeasureTime frame
Dysphagia score;Times of dilatation;Incidence of stricture;Duration of remission of stricture symptoms;Diameter of anastomosis under gastroscope;

Secondary

MeasureTime frame
Incidence of postoperative complications: chest pain, infection, perforation, bleeding, etc;

Countries

China

Contacts

Public ContactShi Lei

The Affiliated Hospital of Southwest Medical University

leishi@swmu.edu.cn+86 13982751821

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026