Identification of abnormal DNA methylation modification of the candidate genes of NOTCH signaling pathway and study on their mechanisms in the tetralogy of Fallot

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100051811

Enrollment

Unknown

Registered

2021-10-05

Start date

2015-06-30

Completion date

Unknown

Last updated

2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tetralogy of Fallot

Interventions

TOF group:Nil

control group :Nil

Eligibility

Sex/Gender

All

Age

1 Years to 3 Years

Inclusion criteria

Inclusion criteria: the TOF group: 1. Signed informed consent; 2. Diagnosed with Tetralogy of Fallot. the control group: 1. Signed informed consent; 2. Children who died accidentally.

Exclusion criteria

Exclusion criteria: the TOF group: chromosome aberration. the control group: 1. Children who died of heart problems; 2. Autopsy found a problem with the heart.

Design outcomes

Primary

Measure	Time frame
The methylation level of the CpG site in the promoter region of the gene;	—

Countries

China

Contacts

Public ContactShengwei

Children's Hospital of Fudan University

sheng4616@126.com+86 13564370238

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026