Cervical degenerative disease
Conditions
Interventions
Group A:Intraoperative local administration of dexamethasone + intravenous administration of physiological saline
Group B:Intravenous administration of dexamethasone + intraoperative local administration of physiological saline
Group C:Intraoperative local and postoperative intravenous administration of physiological saline
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Patients diagnosed with cervical spondylotic radiculopathy based on clinical symptoms, signs, and imaging findings; 3. After standardized conservative treatment, the symptoms are ineffective or the symptoms are progressively aggravated, which affects daily life and work, and requires anterior decompression surgery; 4. The operative segment is located between C3/4-C6/7; 5. NDI score greater than or equal to 30%; 6. Be able to fully comply with this agreement psychologically and physically, and cooperate with the scheduled treatment plan, fill in the form, and cooperate with follow-up visits; 7. After the patient signs the informed consent, it means that the patient has known and agreed to carry out the relevant aspects of this study.
Exclusion criteria
Exclusion criteria: 1. There is a history of cervical spine surgery and bone fusion of adjacent segments. 2. Ossification of the posterior longitudinal ligament or cervical spinal stenosis, spinal fracture, severe osteoporosis or a history of bone metabolic disease. 3. Local infection and ulceration of neck skin, systemic inflammatory disease, uncontrolled diabetes, malignant tumor, active hepatitis, etc. 4. Known to suffer from infectious diseases such as AIDS, syphilis, etc. 5. Suffering from autoimmune disease. 6. Received daily immunosuppressive therapy for more than 1 month in the past 12 months. 7. Hypersensitivity to implant materials (PPEK or titanium alloys) or experimental drugs. 8. Severe obesity, history of drug abuse. 9. Those who have a pregnancy plan during pregnancy or research. 10. Participating in other studies that may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of analgesic drugs used; | — |
Secondary
| Measure | Time frame |
|---|---|
| Therapeutic Index of the Japanese Orthopaedic Association;Visual Analogue Scale for pain;Cervical Spine Disability Index;Health Status Survey Short Form;Dysphagia classification;rusion rate; | — |
Countries
China
Contacts
Public ContactLiu Hao
West China Hospital, Sichuan University
Outcome results
None listed