Acute ischemic stroke
Conditions
Interventions
Placebo group:Standard pharmaceutical therapy
Methylprednisolone group:Standard pharmaceutical therapy and methylprednisolone
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years 2. Presenting with AIS with symptoms within 24 hours from time last known well 3. Baseline National Institutes of Health Stroke Scale (NIHSS) >5 4. Anterior circulation ischemic stroke was determined according to clinical symptoms and imaging examination 5. Baseline Alberta Stroke Program Early CT Score (ASPECTS) ? 3 6. Occlusion of the intracranial internal carotid artery, the M1- or M2-segment of the middle cerebral artery confirmed by CTA, MR angiography, or digital subtraction angiography and planned treatment with EVT 7. Informed consent obtained from patients or their legal representatives.
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage confirmed by cranial computed tomography (CT) or magnetic resonance imaging (MRI); 2. mRS score >= 2 before onset; 3. Pregnant or lactating women; 4. Allergic to contrast agents; 5. Allergic to glucocorticoids; 6. Participating in other clinical trials; 7. Systolic blood pressure > 185 mmHg or diastolic pressure > 110 mmHg, and oral antihypertensive drugs can not control; 8. Genetic or acquired bleeding constitution, lack of anticoagulant factors; Or oral anticoagulants and INR > 1.7; 9. Blood sugar 22.2 mmol/L (400 mg/dl), platelet 220 umol/L [2.5 mg/ dL]); 13. Life expectancy due to any advanced disease < 6 months; 14. Follow-up is not expected to be completed; 15. Intracranial aneurysm and arteriovenous malformation; 16. Brain tumors with imaging mass effect; 17. Systemic infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRS (Modified Rankin Scale) score at 90 days;Death;mRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of MRS scores;Incidence of complications of intracranial hemorrhage;EQ-5D scale score (EuroQol five dimensions questionnaire);Dichotomized mRS score;Gastrointestinal bleeding 7 days after surgery;Pulmonary infection during hospitalization;Ordinal mRS score; | — |
Countries
China
Contacts
Public ContactZi Wenjie, Yang Qingwu
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed